Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

Obesity is clearly becoming a worldwide pandemic and is now considered a disease that recent data have shown it affects more than one third of the adult population in the United States [1]. Obesity affects female reproduction [2-6] since compelling data showed that obese women are more predisposed to subfertility [7], have increased risk of miscarriages [8] and are more prone to having pregnancy complications such as gestational diabetes and preeclampsia [9]. As for subfertility, obese women are more predisposed to anovulation [7], have longer time to spontaneous Abstract